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1n6g

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[[Image:1n6g.png|left|200px]]
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==The structure of immature Dengue-2 prM particles==
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<StructureSection load='1n6g' size='340' side='right' caption='[[1n6g]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n6g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2_puerto_rico/pr159-s1/1969 Dengue virus 2 puerto rico/pr159-s1/1969]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N6G FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n6g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n6g RCSB], [http://www.ebi.ac.uk/pdbsum/1n6g PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/1n6g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Structures of prM-containing dengue and yellow fever virus particles were determined to 16 and 25 A resolution, respectively, by cryoelectron microscopy and image reconstruction techniques. The closely similar structures show 60 icosahedrally organized trimeric spikes on the particle surface. Each spike consists of three prM:E heterodimers, where E is an envelope glycoprotein and prM is the precursor to the membrane protein M. The pre-peptide components of the prM proteins in each spike cover the fusion peptides at the distal ends of the E glycoproteins in a manner similar to the organization of the glycoproteins in the alphavirus spikes. Each heterodimer is associated with an E and a prM transmembrane density. These transmembrane densities represent either an EE or prMprM antiparallel coiled coil by which each protein spans the membrane twice, leaving the C-terminus of each protein on the exterior of the viral membrane, consistent with the predicted membrane-spanning domains of the unprocessed polyprotein.
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{{STRUCTURE_1n6g| PDB=1n6g | SCENE= }}
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Structures of immature flavivirus particles.,Zhang Y, Corver J, Chipman PR, Zhang W, Pletnev SV, Sedlak D, Baker TS, Strauss JH, Kuhn RJ, Rossmann MG EMBO J. 2003 Jun 2;22(11):2604-13. PMID:12773377<ref>PMID:12773377</ref>
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===The structure of immature Dengue-2 prM particles===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12773377}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1n6g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6G OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012773377</ref><references group="xtra"/>
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[[Category: Dengue Virus]]
[[Category: Dengue Virus]]
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[[Category: Dengue virus 2 puerto rico/pr159-s1/1969]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Viruses]]
 
[[Category: Baker, T S.]]
[[Category: Baker, T S.]]
[[Category: Chipman, P R.]]
[[Category: Chipman, P R.]]

Revision as of 16:10, 28 September 2014

The structure of immature Dengue-2 prM particles

1n6g, resolution 16.00Å

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