1fbv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fbv.gif|left|200px]]<br /><applet load="1fbv" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1fbv.gif|left|200px]]
-
caption="1fbv, resolution 2.9&Aring;" />
+
 
-
'''STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES'''<br />
+
{{Structure
 +
|PDB= 1fbv |SIZE=350|CAPTION= <scene name='initialview01'>1fbv</scene>, resolution 2.9&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
 +
|ACTIVITY= [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19]
 +
|GENE=
 +
}}
 +
 
 +
'''STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1FBV is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FBV OCA].
+
1FBV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FBV OCA].
==Reference==
==Reference==
-
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases., Zheng N, Wang P, Jeffrey PD, Pavletich NP, Cell. 2000 Aug 18;102(4):533-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10966114 10966114]
+
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases., Zheng N, Wang P, Jeffrey PD, Pavletich NP, Cell. 2000 Aug 18;102(4):533-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10966114 10966114]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
Line 31: Line 40:
[[Category: zap-70]]
[[Category: zap-70]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:37:03 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:07:04 2008''

Revision as of 09:07, 20 March 2008

Image:1fbv.gif


PDB ID 1fbv

Drag the structure with the mouse to rotate
, resolution 2.9Å
Ligands: and
Activity: Ubiquitin--protein ligase, with EC number 6.3.2.19
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES


Overview

Ubiquitin-protein ligases (E3s) regulate diverse cellular processes by mediating protein ubiquitination. The c-Cbl proto-oncogene is a RING family E3 that recognizes activated receptor tyrosine kinases, promotes their ubiquitination by a ubiquitin-conjugating enzyme (E2) and terminates signaling. The crystal structure of c-Cbl bound to a cognate E2 and a kinase peptide shows how the RING domain recruits the E2. A comparison with a HECT family E3-E2 complex indicates that a common E2 motif is recognized by the two E3 families. The structure reveals a rigid coupling between the peptide binding and the E2 binding domains and a conserved surface channel leading from the peptide to the E2 active site, suggesting that RING E3s may function as scaffolds that position the substrate and the E2 optimally for ubiquitin transfer.

About this Structure

1FBV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases., Zheng N, Wang P, Jeffrey PD, Pavletich NP, Cell. 2000 Aug 18;102(4):533-9. PMID:10966114

Page seeded by OCA on Thu Mar 20 11:07:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fbv"
Personal tools