1ok0

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[[Image:1ok0.png|left|200px]]
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==CRYSTAL STRUCTURE OF TENDAMISTAT==
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<StructureSection load='1ok0' size='340' side='right' caption='[[1ok0]], [[Resolution|resolution]] 0.93&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ok0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_tendae Streptomyces tendae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OK0 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bvn|1bvn]], [[1hoe|1hoe]], [[2ait|2ait]], [[3ait|3ait]], [[4ait|4ait]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ok0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ok0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ok0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ok0 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/1ok0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the proteinaceous alpha-amylase inhibitor tendamistat has been determined at 100 K to a resolution of 0.93 A. The final R factor for all reflections with F &gt; 4sigma(F) is 9.26%. The mean coordinate error for fully occupied protein atoms as derived from full-matrix inversion is 0.018 A. An extended network of multiple discrete conformations has been identified on the side of tendamistat that binds to the target molecule. Most notably, residue Tyr15, which interacts with the glycine-rich loop characteristic of mammalian amylases, and a cluster of amino-acid side chains surrounding it are found in two well defined conformations. The flexibility observed in this crystal structure together with information about residues fixed by lattice contacts in the crystal but found to be mobile in a previous NMR study supports a model in which most of the residues involved in binding are not fixed in the free form of the inhibitor, suggesting an induced-fit type of binding.
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{{STRUCTURE_1ok0| PDB=1ok0 | SCENE= }}
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Structure of the alpha-amylase inhibitor tendamistat at 0.93 A.,Konig V, Vertesy L, Schneider TR Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1737-43. Epub 2003, Sep 19. PMID:14501112<ref>PMID:14501112</ref>
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===CRYSTAL STRUCTURE OF TENDAMISTAT===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_14501112}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1ok0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_tendae Streptomyces tendae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OK0 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:014501112</ref><ref group="xtra">PMID:018754631</ref><references group="xtra"/>
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[[Category: Streptomyces tendae]]
[[Category: Streptomyces tendae]]
[[Category: Koenig, V.]]
[[Category: Koenig, V.]]

Revision as of 16:59, 28 September 2014

CRYSTAL STRUCTURE OF TENDAMISTAT

1ok0, resolution 0.93Å

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