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1ngt

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[[Image:1ngt.png|left|200px]]
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==The Role of Minor Groove Functional Groups in DNA Hydration==
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<StructureSection load='1ngt' size='340' side='right' caption='[[1ngt]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ngt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NGT FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTR:(5-METHYL-6-OXO-1,6-DIHYDRO-PYRIDIN-3-YL)-1,2-DIDEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>MTR</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ngt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ngt RCSB], [http://www.ebi.ac.uk/pdbsum/1ngt PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove 'spine of hydration' is destabilized but essentially intact.
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{{STRUCTURE_1ngt| PDB=1ngt | SCENE= }}
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The role of minor groove functional groups in DNA hydration.,Woods KK, Lan T, McLaughlin LW, Williams LD Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:12595562<ref>PMID:12595562</ref>
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===The Role of Minor Groove Functional Groups in DNA Hydration===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12595562}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1ngt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA].
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</StructureSection>
[[Category: Lan, T.]]
[[Category: Lan, T.]]
[[Category: McLaughlin, L W.]]
[[Category: McLaughlin, L W.]]

Revision as of 17:53, 28 September 2014

The Role of Minor Groove Functional Groups in DNA Hydration

1ngt, resolution 2.04Å

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