This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1l1w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1l1w" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:1l1w.png|left|200px]]
+
==NMR structure of a SRP19 binding domain in human SRP RNA==
 +
<StructureSection load='1l1w' size='340' side='right' caption='[[1l1w]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1l1w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L1W FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l1w RCSB], [http://www.ebi.ac.uk/pdbsum/1l1w PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Assembly of the human signal recognition particle (SRP) requires SRP19 protein to bind to helices 6 and 8 of SRP RNA. In the present study, structure of a 29-mer RNA composing the SRP19 binding site in helix 6 was determined by NMR spectroscopy. The two A:C mismatches were continuously stacked to each other and formed wobble type A:C base pairs. The GGAG tetraloop in helix 6 was found to adopt a similar conformation to that of GNRA tetraloop, suggesting that these tetraloops are included in an extensive new motif GNRR. Compared with the crystal structure of helix 6 in complex with SRP19 determined previously, the GGAG tetraloop in the complex was found to adopt a similar conformation to the free form, although the loop structure becomes more open upon SRP19 binding. Thus, SRP19 is thought to recognize the overall fold of the GGAG loop.
-
{{STRUCTURE_1l1w| PDB=1l1w | SCENE= }}
+
Solution structure of a SRP19 binding domain in human SRP RNA.,Sakamoto T, Morita S, Tabata K, Nakamura K, Kawai G J Biochem. 2002 Aug;132(2):177-82. PMID:12153712<ref>PMID:12153712</ref>
-
===NMR structure of a SRP19 binding domain in human SRP RNA===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_12153712}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1l1w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA].
+
</StructureSection>
[[Category: Kawai, G.]]
[[Category: Kawai, G.]]
[[Category: Morita, S.]]
[[Category: Morita, S.]]

Revision as of 18:21, 28 September 2014

NMR structure of a SRP19 binding domain in human SRP RNA

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l1w"
Views
Personal tools
Navigation
Toolbox