1pjc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1pjc" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:1pjc.png|left|200px]]
+
==L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD==
 +
<StructureSection load='1pjc' size='340' side='right' caption='[[1pjc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1pjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJC FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
 +
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_dehydrogenase Alanine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.1 1.4.1.1] </span></td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pjc RCSB], [http://www.ebi.ac.uk/pdbsum/1pjc PDBsum]</span></td></tr>
 +
<table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pj/1pjc_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The structure of the hexameric L-alanine dehydrogenase from Phormidium lapideum reveals that the subunit is constructed from two domains, each having the common dinucleotide binding fold. Despite there being no sequence similarity, the fold of alanine dehydrogenase is closely related to that of the family of D-2-hydroxyacid dehydrogenases, with a similar location of the active site, suggesting that these enzymes are related by divergent evolution. L-alanine dehydrogenase and the 2-hydroxyacid dehydrogenases also use equivalent functional groups to promote substrate recognition and catalysis. However, they are arranged differently on the enzyme surface, which has the effect of directing opposite faces of the keto acid to the dinucleotide in each case, forcing a change in absolute configuration of the product.
-
{{STRUCTURE_1pjc| PDB=1pjc | SCENE= }}
+
Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.,Baker PJ, Sawa Y, Shibata H, Sedelnikova SE, Rice DW Nat Struct Biol. 1998 Jul;5(7):561-7. PMID:9665169<ref>PMID:9665169</ref>
-
===L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_9665169}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1pjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJC OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:009665169</ref><ref group="xtra">PMID:011178916</ref><references group="xtra"/>
+
[[Category: Alanine dehydrogenase]]
[[Category: Alanine dehydrogenase]]
[[Category: Phormidium lapideum]]
[[Category: Phormidium lapideum]]

Revision as of 20:29, 28 September 2014

L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD

1pjc, resolution 2.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pjc"
Views
Personal tools
Navigation
Toolbox