1fin

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[[Image:1fin.jpg|left|200px]]<br /><applet load="1fin" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1fin.jpg|left|200px]]
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caption="1fin, resolution 2.3&Aring;" />
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'''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX'''<br />
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{{Structure
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|PDB= 1fin |SIZE=350|CAPTION= <scene name='initialview01'>1fin</scene>, resolution 2.3&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1FIN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIN OCA].
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1FIN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIN OCA].
==Reference==
==Reference==
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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7630397 7630397]
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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7630397 7630397]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: phosphorylation]]
[[Category: phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:39:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:09:38 2008''

Revision as of 09:09, 20 March 2008

Image:1fin.jpg


PDB ID 1fin

Drag the structure with the mouse to rotate
, resolution 2.3Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX


Overview

The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes in its PSTAIRE helix and T-loop. These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.

About this Structure

1FIN is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:7630397

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