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1p9f
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| - | [[ | + | ==NMR Structure of Neurokinin B from DYANA== |
| + | <StructureSection load='1p9f' size='340' side='right' caption='[[1p9f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1p9f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P9F FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p9f RCSB], [http://www.ebi.ac.uk/pdbsum/1p9f PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Neurokinin B (NKB), a decapeptide of mammalian origin exhibits a variety of biological activities such as regulatory functions in reproduction, pre-eclampsia and neuroprotection in Alzheimer's disease. In order to gain insight into structure-function relationship, three-dimensional structure of NKB has been investigated using CD spectropolarimetry and two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in aqueous and membrane mimetic solvents. Unambiguous NMR assignments of resonances have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and Nuclear Overhauser Effect Spectroscopy (NOESY) experiments. Distance constraints obtained from the NMR data have been used to generate a family of structures, which have been refined using restrained energy minimization and dynamics. Our data show that a helical structure is induced in NKB, in presence of perdeuterated dodecyl phosphocholine (DPC) micelles, a membrane model system. Further, the conformation adopted by NKB in presence of DPC micelles represents a structural motif typical of neurokinin-3 selective agonists. | ||
| - | + | Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles.,Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:15317475<ref>PMID:15317475</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Baquer, N Z.]] | [[Category: Baquer, N Z.]] | ||
[[Category: Chandrashekar, I R.]] | [[Category: Chandrashekar, I R.]] | ||
Revision as of 21:26, 28 September 2014
NMR Structure of Neurokinin B from DYANA
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