1p85

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[[Image:1p85.png|left|200px]]
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==Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome==
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<StructureSection load='1p85' size='340' side='right' caption='[[1p85]], [[Resolution|resolution]] 12.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p85]] is a 26 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P85 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gix|1gix]], [[1giy|1giy]], [[1jj2|1jj2]], [[1ibl|1ibl]], [[1lnr|1lnr]], [[1m5g|1m5g]], [[1p6g|1p6g]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p85 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p85 RCSB], [http://www.ebi.ac.uk/pdbsum/1p85 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/1p85_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cryo-EM density maps showing the 70S ribosome of E. coli in two different functional states related by a ratchet-like motion were analyzed using real-space refinement. Comparison of the two resulting atomic models shows that the ribosome changes from a compact structure to a looser one, coupled with the rearrangement of many of the proteins. Furthermore, in contrast to the unchanged inter-subunit bridges formed wholly by RNA, the bridges involving proteins undergo large conformational changes following the ratchet-like motion, suggesting an important role of ribosomal proteins in facilitating the dynamics of translation.
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{{STRUCTURE_1p85| PDB=1p85 | SCENE= }}
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Study of the structural dynamics of the E coli 70S ribosome using real-space refinement.,Gao H, Sengupta J, Valle M, Korostelev A, Eswar N, Stagg SM, Van Roey P, Agrawal RK, Harvey SC, Sali A, Chapman MS, Frank J Cell. 2003 Jun 13;113(6):789-801. PMID:12809609<ref>PMID:12809609</ref>
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===Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12809609}}
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==About this Structure==
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[[1p85]] is a 26 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P85 OCA].
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==See Also==
==See Also==
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*[[Ribosomal protein L11|Ribosomal protein L11]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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*[[Ribosomal protein L13|Ribosomal protein L13]]
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== References ==
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*[[Ribosomal protein L14|Ribosomal protein L14]]
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<references/>
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*[[Ribosomal protein L15|Ribosomal protein L15]]
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__TOC__
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*[[Ribosomal protein L16|Ribosomal protein L16]]
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</StructureSection>
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*[[Ribosomal protein L17|Ribosomal protein L17]]
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*[[Ribosomal protein L18|Ribosomal protein L18]]
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*[[Ribosomal protein L19|Ribosomal protein L19]]
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*[[Ribosomal protein L2|Ribosomal protein L2]]
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*[[Ribosomal protein L20|Ribosomal protein L20]]
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*[[Ribosomal protein L22|Ribosomal protein L22]]
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*[[Ribosomal protein L23|Ribosomal protein L23]]
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*[[Ribosomal protein L24|Ribosomal protein L24]]
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*[[Ribosomal protein L25|Ribosomal protein L25]]
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*[[Ribosomal protein L27|Ribosomal protein L27]]
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*[[Ribosomal protein L29|Ribosomal protein L29]]
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*[[Ribosomal protein L3|Ribosomal protein L3]]
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*[[Ribosomal protein L30|Ribosomal protein L30]]
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*[[Ribosomal protein L32|Ribosomal protein L32]]
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*[[Ribosomal protein L33|Ribosomal protein L33]]
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*[[Ribosomal protein L36|Ribosomal protein L36]]
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*[[Ribosomal protein L4|Ribosomal protein L4]]
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*[[Ribosomal protein L5|Ribosomal protein L5]]
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*[[Ribosomal protein L6|Ribosomal protein L6]]
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*[[Ribosomal protein L9|Ribosomal protein L9]]
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==Reference==
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<ref group="xtra">PMID:012809609</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Agrawal, R K.]]
[[Category: Agrawal, R K.]]

Revision as of 21:32, 28 September 2014

Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome

1p85, resolution 12.30Å

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OCA

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