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1fli
From Proteopedia
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| - | [[Image:1fli.gif|left|200px]] | + | [[Image:1fli.gif|left|200px]] |
| - | + | ||
| - | '''DNA-BINDING DOMAIN OF FLI-1''' | + | {{Structure |
| + | |PDB= 1fli |SIZE=350|CAPTION= <scene name='initialview01'>1fli</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= T7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''DNA-BINDING DOMAIN OF FLI-1''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1FLI is a [ | + | 1FLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLI OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of the ets domain of Fli-1 when bound to DNA., Liang H, Mao X, Olejniczak ET, Nettesheim DG, Yu L, Meadows RP, Thompson CB, Fesik SW, Nat Struct Biol. 1994 Dec;1(12):871-5. PMID:[http:// | + | Solution structure of the ets domain of Fli-1 when bound to DNA., Liang H, Mao X, Olejniczak ET, Nettesheim DG, Yu L, Meadows RP, Thompson CB, Fesik SW, Nat Struct Biol. 1994 Dec;1(12):871-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7773776 7773776] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 23: | Line 32: | ||
[[Category: transcription/dna]] | [[Category: transcription/dna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:10:38 2008'' |
Revision as of 09:10, 20 March 2008
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| Gene: | T7 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
DNA-BINDING DOMAIN OF FLI-1
Overview
Members of the ets family of transcription factors share a conserved DNA-binding domain, the ets domain. By using multidimensional NMR, we have determined the structure of the ets domain of human Fli-1 in the DNA-bound form. It consists of three alpha-helices and a four-stranded beta-sheet, similar to structures of the class of helix-turn-helix DNA binding proteins first found in the catabolite activator protein of Escherichia coli. NMR and mutagenesis experiments suggest that in comparison to structurally related proteins, the ets domain uses a new variation of the helix-turn-helix motif for binding to DNA.
About this Structure
1FLI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the ets domain of Fli-1 when bound to DNA., Liang H, Mao X, Olejniczak ET, Nettesheim DG, Yu L, Meadows RP, Thompson CB, Fesik SW, Nat Struct Biol. 1994 Dec;1(12):871-5. PMID:7773776
Page seeded by OCA on Thu Mar 20 11:10:38 2008
