1fmq

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[[Image:1fmq.gif|left|200px]]<br /><applet load="1fmq" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1fmq.gif|left|200px]]
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caption="1fmq, resolution 2.&Aring;" />
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'''Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG'''<br />
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{{Structure
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|PDB= 1fmq |SIZE=350|CAPTION= <scene name='initialview01'>1fmq</scene>, resolution 2.&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1FMQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=D34:'>D34</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA].
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1FMQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA].
==Reference==
==Reference==
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DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11128631 11128631]
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DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11128631 11128631]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Boykin, D W.]]
[[Category: Boykin, D W.]]
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[[Category: dna-drug minor groove complex]]
[[Category: dna-drug minor groove complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:40:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:11:16 2008''

Revision as of 09:11, 20 March 2008

Image:1fmq.gif


PDB ID 1fmq

Drag the structure with the mouse to rotate
, resolution 2.Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG


Overview

2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.

About this Structure

1FMQ is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631

Page seeded by OCA on Thu Mar 20 11:11:16 2008

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