1qmc
From Proteopedia
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| - | [[ | + | ==C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES== |
| + | <StructureSection load='1qmc' size='340' side='right' caption='[[1qmc]], [[NMR_Ensembles_of_Models | 42 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1qmc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QMC FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a5v|1a5v]], [[1a5w|1a5w]], [[1a5x|1a5x]], [[1aub|1aub]], [[1b9d|1b9d]], [[1b9f|1b9f]], [[1bhl|1bhl]], [[1bi4|1bi4]], [[1bis|1bis]], [[1biu|1biu]], [[1bl3|1bl3]], [[1wja|1wja]], [[1wjb|1wjb]], [[1wjc|1wjc]], [[1wjd|1wjd]], [[1wje|1wje]], [[1wjf|1wjf]], [[2itg|2itg]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qmc RCSB], [http://www.ebi.ac.uk/pdbsum/1qmc PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy. The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a five-stranded beta-barrel that resembles that of Src homology 3 domains. Compared with our previously reported structure, the structure is now defined far better. The final 42 structures display a back-bone root mean square deviation versus the average of 0.46 A. Correlation of the structure with recent mutagenesis studies suggests two possible models for DNA binding. Proteins 1999;36:556-564. | ||
| - | + | Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase.,Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R, Kaptein R Proteins. 1999 Sep 1;36(4):556-64. PMID:10450096<ref>PMID:10450096</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[HIV integrase|HIV integrase]] | *[[HIV integrase|HIV integrase]] | ||
*[[Retroviral Integrase|Retroviral Integrase]] | *[[Retroviral Integrase|Retroviral Integrase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Boelens, R.]] | [[Category: Boelens, R.]] | ||
Revision as of 22:41, 28 September 2014
C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES
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