1fqy

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[[Image:1fqy.jpg|left|200px]]<br /><applet load="1fqy" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1fqy.jpg|left|200px]]
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caption="1fqy, resolution 3.80&Aring;" />
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'''STRUCTURE OF AQUAPORIN-1 AT 3.8 A RESOLUTION BY ELECTRON CRYSTALLOGRAPHY'''<br />
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{{Structure
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|PDB= 1fqy |SIZE=350|CAPTION= <scene name='initialview01'>1fqy</scene>, resolution 3.80&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF AQUAPORIN-1 AT 3.8 A RESOLUTION BY ELECTRON CRYSTALLOGRAPHY'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1FQY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQY OCA].
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1FQY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQY OCA].
==Reference==
==Reference==
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Structural determinants of water permeation through aquaporin-1., Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A, Fujiyoshi Y, Nature. 2000 Oct 5;407(6804):599-605. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11034202 11034202]
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Structural determinants of water permeation through aquaporin-1., Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A, Fujiyoshi Y, Nature. 2000 Oct 5;407(6804):599-605. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11034202 11034202]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: water channel]]
[[Category: water channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:41:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:12:48 2008''

Revision as of 09:12, 20 March 2008

Image:1fqy.jpg


PDB ID 1fqy

Drag the structure with the mouse to rotate
, resolution 3.80Å
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF AQUAPORIN-1 AT 3.8 A RESOLUTION BY ELECTRON CRYSTALLOGRAPHY


Contents

Overview

Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels. Here we describe an atomic model of AQP1 at 3.8A resolution from electron crystallographic data. Multiple highly conserved amino-acid residues stabilize the novel fold of AQP1. The aqueous pathway is lined with conserved hydrophobic residues that permit rapid water transport, whereas the water selectivity is due to a constriction of the pore diameter to about 3 A over a span of one residue. The atomic model provides a possible molecular explanation to a longstanding puzzle in physiology-how membranes can be freely permeable to water but impermeable to protons.

Disease

Known diseases associated with this structure: Aquaporin-1 deficiency OMIM:[107776], Blood group, Colton OMIM:[107776]

About this Structure

1FQY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural determinants of water permeation through aquaporin-1., Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A, Fujiyoshi Y, Nature. 2000 Oct 5;407(6804):599-605. PMID:11034202

Page seeded by OCA on Thu Mar 20 11:12:48 2008

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