2j12

From Proteopedia

Revision as of 15:16, 30 October 2007

AD37 FIBRE HEAD IN COMPLEX WITH CAR D1

Overview

Adenovirus fibers from most serotypes bind the D1 domain of coxsackie and, adenovirus receptor (CAR), although the binding residues are not strictly, conserved. To understand this further, we determined the crystal, structures of canine adenovirus serotype 2 (CAV-2) and the human, adenovirus serotype 37 (HAd37) in complex with human CAR D1 at 2.3 and, 1.5A resolution, respectively. Structure comparison with the HAd12 fiber, head-CAR D1 complex showed that the overall topology of the interaction is, conserved but that the interfaces differ in number and identity of, interacting residues, shape complementarity, and degree of conformational, adaptation. Using surface plasmon resonance, we characterized the binding, affinity to CAR D1 of wild type and mutant CAV-2 and HAd37 fiber heads. We, ... [(full description)]

About this Structure

2J12 is a [Protein complex] structure of sequences from [Homo sapiens] and [Human adenovirus type 49] with CA as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor., Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S, J Biol Chem. 2006 Nov 3;281(44):33704-16. Epub 2006 Aug 21. PMID:16923808

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