2a4g

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[[Image:2a4g.png|left|200px]]
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==Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound==
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<StructureSection load='2a4g' size='340' side='right' caption='[[2a4g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2a4g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4G FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNH:({1-[1-CARBAMOYL-PHENYL-METHYL)-CARBAMOYL]-METHYL}-AMINOOXALYL)-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL)-CYCLOHEXYL-METHYL)-CARBAMIC+ACID+ISOBUTYL+ESTER'>UNH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4g RCSB], [http://www.ebi.ac.uk/pdbsum/2a4g PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have discovered that introduction of appropriate amino acid derivatives at P'2 position improved the binding potency of P3-capped alpha-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound to the protease revealed the importance of the P'2 moiety.
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{{STRUCTURE_2a4g| PDB=2a4g | SCENE= }}
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Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.,Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. PMID:16087332<ref>PMID:16087332</ref>
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===Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16087332}}
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==About this Structure==
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[[2a4g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4G OCA].
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==See Also==
==See Also==
*[[Helicase|Helicase]]
*[[Helicase|Helicase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016087332</ref><ref group="xtra">PMID:008861917</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Arasappan, A.]]
[[Category: Arasappan, A.]]

Revision as of 04:06, 29 September 2014

Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound

2a4g, resolution 2.50Å

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