2ho6

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[[Image:2ho6.png|left|200px]]
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==Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme==
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<StructureSection load='2ho6' size='340' side='right' caption='[[2ho6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ho6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HO6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ho7|2ho7]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ho6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ho6 RCSB], [http://www.ebi.ac.uk/pdbsum/2ho6 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.
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{{STRUCTURE_2ho6| PDB=2ho6 | SCENE= }}
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Structural basis of glmS ribozyme activation by glucosamine-6-phosphate.,Klein DJ, Ferre-D'Amare AR Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543<ref>PMID:16990543</ref>
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===Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16990543}}
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==About this Structure==
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[[2ho6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO6 OCA].
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==See Also==
==See Also==
*[[Ribozyme|Ribozyme]]
*[[Ribozyme|Ribozyme]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016990543</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Amare, A R.Ferre-D.]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Klein, D J.]]
[[Category: Klein, D J.]]

Revision as of 04:17, 29 September 2014

Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme

2ho6, resolution 2.80Å

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