1g44
From Proteopedia
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| - | [[Image:1g44.jpg|left|200px]] | + | [[Image:1g44.jpg|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS''' | + | {{Structure |
| + | |PDB= 1g44 |SIZE=350|CAPTION= <scene name='initialview01'>1g44</scene>, resolution 2.6Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''CRYSTAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1G44 is a [ | + | 1G44 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G44 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans., Murthy KH, Smith SA, Ganesh VK, Judge KW, Mullin N, Barlow PN, Ogata CM, Kotwal GJ, Cell. 2001 Jan 26;104(2):301-11. PMID:[http:// | + | Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans., Murthy KH, Smith SA, Ganesh VK, Judge KW, Mullin N, Barlow PN, Ogata CM, Kotwal GJ, Cell. 2001 Jan 26;104(2):301-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11207370 11207370] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
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[[Category: module]] | [[Category: module]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:17:55 2008'' |
Revision as of 09:17, 20 March 2008
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CRYSTAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS
Overview
Vaccinia virus complement control protein (VCP) inhibits both pathways of complement activation through binding the third and fourth components. A homolog of mammalian regulators of complement activation, its ability to bind heparin endows VCP with additional activities of significance to viral infectivity. The structure of VCP reveals a highly extended molecule with a putative heparin recognition site at its C-terminal end. A second cluster of positive charges provides a possibly overlapping binding site for both heparin and complement components. Experiments suggested by the structure indicate that VCP can bind heparin and control complement simultaneously. This, the structure of any intact regulator of complement activation, along with attendant functional insights, will stimulate the design of new therapeutic inhibitors of complement.
About this Structure
1G44 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans., Murthy KH, Smith SA, Ganesh VK, Judge KW, Mullin N, Barlow PN, Ogata CM, Kotwal GJ, Cell. 2001 Jan 26;104(2):301-11. PMID:11207370
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