2gdt

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[[Image:2gdt.png|left|200px]]
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==NMR Structure of the nonstructural protein 1 (nsp1) from the SARS coronavirus==
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<StructureSection load='2gdt' size='340' side='right' caption='[[2gdt]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GDT FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gdt RCSB], [http://www.ebi.ac.uk/pdbsum/2gdt PDBsum], [http://www.topsan.org/Proteins/JCSG/2gdt TOPSAN]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The nonstructural protein 1 (nsp1) of the severe acute respiratory syndrome coronavirus has 179 residues and is the N-terminal cleavage product of the viral replicase polyprotein that mediates RNA replication and processing. The specific function of nsp1 is not known. Here we report the nuclear magnetic resonance structure of the nsp1 segment from residue 13 to 128, which represents a novel alpha/beta-fold formed by a mixed parallel/antiparallel six-stranded beta-barrel, an alpha-helix covering one opening of the barrel, and a 3(10)-helix alongside the barrel. We further characterized the full-length 179-residue protein and show that the polypeptide segments of residues 1 to 12 and 129 to 179 are flexibly disordered. The structure is analyzed in a search for possible correlations with the recently reported activity of nsp1 in the degradation of mRNA.
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{{STRUCTURE_2gdt| PDB=2gdt | SCENE= }}
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Novel beta-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus.,Almeida MS, Johnson MA, Herrmann T, Geralt M, Wuthrich K J Virol. 2007 Apr;81(7):3151-61. Epub 2007 Jan 3. PMID:17202208<ref>PMID:17202208</ref>
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===NMR Structure of the nonstructural protein 1 (nsp1) from the SARS coronavirus===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17202208}}
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==About this Structure==
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[[2gdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDT OCA].
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==See Also==
==See Also==
*[[Nonstructural protein|Nonstructural protein]]
*[[Nonstructural protein|Nonstructural protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017202208</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Sars coronavirus]]
[[Category: Sars coronavirus]]
[[Category: Almeida, M S.]]
[[Category: Almeida, M S.]]

Revision as of 05:23, 29 September 2014

NMR Structure of the nonstructural protein 1 (nsp1) from the SARS coronavirus

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