1g6o

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[[Image:1g6o.gif|left|200px]]<br /><applet load="1g6o" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1g6o.gif|left|200px]]
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caption="1g6o, resolution 2.50&Aring;" />
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'''CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP'''<br />
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{{Structure
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|PDB= 1g6o |SIZE=350|CAPTION= <scene name='initialview01'>1g6o</scene>, resolution 2.50&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1G6O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] with <scene name='pdbligand=ADP:'>ADP</scene> and <scene name='pdbligand=PEG:'>PEG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6O OCA].
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1G6O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6O OCA].
==Reference==
==Reference==
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Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system., Yeo HJ, Savvides SN, Herr AB, Lanka E, Waksman G, Mol Cell. 2000 Dec;6(6):1461-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11163218 11163218]
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Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system., Yeo HJ, Savvides SN, Herr AB, Lanka E, Waksman G, Mol Cell. 2000 Dec;6(6):1461-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11163218 11163218]
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: atpase]]
[[Category: atpase]]
[[Category: mcsg]]
[[Category: mcsg]]
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[[Category: midwest center for structural genomics]]
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[[Category: midwest center for structural genomic]]
[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: type iv secretion system]]
[[Category: type iv secretion system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:46:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:18:56 2008''

Revision as of 09:18, 20 March 2008

Image:1g6o.gif


PDB ID 1g6o

Drag the structure with the mouse to rotate
, resolution 2.50Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP


Overview

The type IV secretion system of Helicobacter pylori consists of 10--15 proteins responsible for transport of the transforming protein CagA into target epithelial cells. Secretion of CagA crucially depends on the hexameric ATPase, HP0525, a member of the VirB11-PulE family. We present the crystal structure of a binary complex of HP0525 bound to ADP. Each monomer consists of two domains formed by the N- and C-terminal halves of the sequence. ADP is bound at the interface between the two domains. In the hexamer, the N- and C-terminal domains form two rings, which together form a chamber open on one side and closed on the other. A model is proposed in which HP0525 functions as an inner membrane pore, the closure and opening of which is regulated by ATP binding and ADP release.

About this Structure

1G6O is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.

Reference

Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system., Yeo HJ, Savvides SN, Herr AB, Lanka E, Waksman G, Mol Cell. 2000 Dec;6(6):1461-72. PMID:11163218

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