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2qij

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[[Image:2qij.png|left|200px]]
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==Hepatitis B Capsid Protein with an N-terminal extension modelled into 8.9 A data.==
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<StructureSection load='2qij' size='340' side='right' caption='[[2qij]], [[Resolution|resolution]] 8.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qij]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus_subtype_adyw Hepatitis b virus subtype adyw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QIJ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qgt|1qgt]], [[2g34|2g34]], [[2g33|2g33]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10419 Hepatitis B virus subtype adyw])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qij RCSB], [http://www.ebi.ac.uk/pdbsum/2qij PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/2qij_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hepatitis B core (HBc) particles have been extensively exploited as carriers for foreign immunological epitopes in the development of multicomponent vaccines and diagnostic reagents. Crystals of the T = 4 HBc particle were grown in PEG 20,000, ammonium sulfate and various types of alcohols. A temperature jump from 277 or 283 to 290 K was found to enhance crystal growth. A crystal grown using MPD as a cryoprotectant diffracted X-rays to 7.7 A resolution and data were collected to 99.6% completeness at 8.9 A. The crystal belongs to space group P2(1)2(1)2(1), with unit-cell parameters a = 352.3, b = 465.5, c = 645.0 A. The electron-density map reveals a protrusion that is consistent with the N-terminus extending out from the surface of the capsid. The structure presented here supports the idea that N-terminal insertions can be exploited in the development of diagnostic reagents, multicomponent vaccines and delivery vehicles into mammalian cells.
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{{STRUCTURE_2qij| PDB=2qij | SCENE= }}
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Crystallization and X-ray analysis of the T = 4 particle of hepatitis B capsid protein with an N-terminal extension.,Tan WS, McNae IW, Ho KL, Walkinshaw MD Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):642-7. Epub 2007 Jul 21. PMID:17671358<ref>PMID:17671358</ref>
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===Hepatitis B Capsid Protein with an N-terminal extension modelled into 8.9 A data.===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17671358}}
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==About this Structure==
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[[2qij]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus_subtype_adyw Hepatitis b virus subtype adyw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QIJ OCA].
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==See Also==
==See Also==
*[[Virus coat protein|Virus coat protein]]
*[[Virus coat protein|Virus coat protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017671358</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Hepatitis b virus subtype adyw]]
[[Category: Hepatitis b virus subtype adyw]]
[[Category: Ho, K L.]]
[[Category: Ho, K L.]]

Revision as of 06:34, 29 September 2014

Hepatitis B Capsid Protein with an N-terminal extension modelled into 8.9 A data.

2qij, resolution 8.90Å

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