2ve9

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[[Image:2ve9.png|left|200px]]
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==XRAY STRUCTURE OF KOPS BOUND GAMMA DOMAIN OF FTSK (P. AERUGINOSA)==
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<StructureSection load='2ve9' size='340' side='right' caption='[[2ve9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ve9]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VE9 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2iuu|2iuu]], [[2iut|2iut]], [[2j5o|2j5o]], [[2ve8|2ve8]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ve9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ve9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ve9 RCSB], [http://www.ebi.ac.uk/pdbsum/2ve9 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2ve9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dimeric circular chromosomes, formed by recombination between monomer sisters, cannot be segregated to daughter cells at cell division. XerCD site-specific recombination at the Escherichia coli dif site converts these dimers to monomers in a reaction that requires the DNA translocase FtsK. Short DNA sequences, KOPS (GGGNAGGG), which are polarized toward dif in the chromosome, direct FtsK translocation. FtsK interacts with KOPS through a C-terminal winged helix domain gamma. The crystal structure of three FtsKgamma domains bound to 8 bp KOPS DNA demonstrates how three gamma domains recognize KOPS. Using covalently linked dimers of FtsK, we infer that three gamma domains per hexamer are sufficient to recognize KOPS and load FtsK and subsequently activate recombination at dif. During translocation, FtsK fails to recognize an inverted KOPS sequence. Therefore, we propose that KOPS act solely as a loading site for FtsK, resulting in a unidirectionally oriented hexameric motor upon DNA.
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{{STRUCTURE_2ve9| PDB=2ve9 | SCENE= }}
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Molecular mechanism of sequence-directed DNA loading and translocation by FtsK.,Lowe J, Ellonen A, Allen MD, Atkinson C, Sherratt DJ, Grainge I Mol Cell. 2008 Aug 22;31(4):498-509. PMID:18722176<ref>PMID:18722176</ref>
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===XRAY STRUCTURE OF KOPS BOUND GAMMA DOMAIN OF FTSK (P. AERUGINOSA)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18722176}}
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==About this Structure==
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[[2ve9]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VE9 OCA].
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==See Also==
==See Also==
*[[Tubulin|Tubulin]]
*[[Tubulin|Tubulin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018722176</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Allen, M D.]]
[[Category: Allen, M D.]]

Revision as of 07:43, 29 September 2014

XRAY STRUCTURE OF KOPS BOUND GAMMA DOMAIN OF FTSK (P. AERUGINOSA)

2ve9, resolution 1.90Å

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