1gen

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[[Image:1gen.gif|left|200px]]<br /><applet load="1gen" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1gen.gif|left|200px]]
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caption="1gen, resolution 2.15&Aring;" />
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'''C-TERMINAL DOMAIN OF GELATINASE A'''<br />
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{{Structure
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|PDB= 1gen |SIZE=350|CAPTION= <scene name='initialview01'>1gen</scene>, resolution 2.15&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24]
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|GENE= HUMAN GELATINASE A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''C-TERMINAL DOMAIN OF GELATINASE A'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1GEN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GEN OCA].
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1GEN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GEN OCA].
==Reference==
==Reference==
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Crystal structure of the haemopexin-like C-terminal domain of gelatinase A., Libson AM, Gittis AG, Collier IE, Marmer BL, Goldberg GI, Lattman EE, Nat Struct Biol. 1995 Nov;2(11):938-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7583664 7583664]
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Crystal structure of the haemopexin-like C-terminal domain of gelatinase A., Libson AM, Gittis AG, Collier IE, Marmer BL, Goldberg GI, Lattman EE, Nat Struct Biol. 1995 Nov;2(11):938-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7583664 7583664]
[[Category: Gelatinase A]]
[[Category: Gelatinase A]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: metalloprotease]]
[[Category: metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:49:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:22:06 2008''

Revision as of 09:22, 20 March 2008

Image:1gen.gif


PDB ID 1gen

Drag the structure with the mouse to rotate
, resolution 2.15Å
Ligands: , , and
Gene: HUMAN GELATINASE A (Homo sapiens)
Activity: Gelatinase A, with EC number 3.4.24.24
Coordinates: save as pdb, mmCIF, xml



C-TERMINAL DOMAIN OF GELATINASE A


Contents

Overview

The crystal structure of the haemopexin-like C-terminal domain of gelatinase A reveals that it is a four-bladed beta-propeller protein. The four blades are arranged around a channel-like opening in which Ca2+ and a Na-Cl+ ion pair are bound.

Disease

Known diseases associated with this structure: Osteolysis, idiopathic, Saudi type OMIM:[120360], Winchester syndrome OMIM:[120360]

About this Structure

1GEN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the haemopexin-like C-terminal domain of gelatinase A., Libson AM, Gittis AG, Collier IE, Marmer BL, Goldberg GI, Lattman EE, Nat Struct Biol. 1995 Nov;2(11):938-42. PMID:7583664

Page seeded by OCA on Thu Mar 20 11:22:06 2008

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