2wwa

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[[Image:2wwa.png|left|200px]]
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==CRYO-EM STRUCTURE OF IDLE YEAST SSH1 COMPLEX BOUND TO THE YEAST 80S RIBOSOME==
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<StructureSection load='2wwa' size='340' side='right' caption='[[2wwa]], [[Resolution|resolution]] 8.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wwa]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WWA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k5y|1k5y]], [[1s1i|1s1i]], [[2wwb|2wwb]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wwa RCSB], [http://www.ebi.ac.uk/pdbsum/2wwa PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2wwa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. Although Sec complexes can form oligomers, it has been suggested that a single copy may serve as an active PCC. We determined subnanometer-resolution cryo-electron microscopy structures of eukaryotic ribosome-Sec61 complexes. In combination with biochemical data, we found that in both idle and active states, the Sec complex is not oligomeric and interacts mainly via two cytoplasmic loops with the universal ribosomal adaptor site. In the active state, the ribosomal tunnel and a central pore of the monomeric PCC were occupied by the nascent chain, contacting loop 6 of the Sec complex. This provides a structural basis for the activity of a solitary Sec complex in cotranslational protein translocation.
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{{STRUCTURE_2wwa| PDB=2wwa | SCENE= }}
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Structure of monomeric yeast and Mammalian sec61 complexes interacting with the translating ribosome.,Becker T, Bhushan S, Jarasch A, Armache JP, Funes S, Jossinet F, Gumbart J, Mielke T, Berninghausen O, Schulten K, Westhof E, Gilmore R, Mandon EC, Beckmann R Science. 2009 Dec 4;326(5958):1369-73. Epub 2009 Oct 29. PMID:19933108<ref>PMID:19933108</ref>
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===CRYO-EM STRUCTURE OF IDLE YEAST SSH1 COMPLEX BOUND TO THE YEAST 80S RIBOSOME===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19933108}}
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==About this Structure==
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[[2wwa]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWA OCA].
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==See Also==
==See Also==
*[[Ribosomal protein L17|Ribosomal protein L17]]
*[[Ribosomal protein L17|Ribosomal protein L17]]
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*[[Ribosomal protein L19|Ribosomal protein L19]]
*[[Ribosomal protein L23|Ribosomal protein L23]]
*[[Ribosomal protein L23|Ribosomal protein L23]]
*[[Ribosomal protein L25|Ribosomal protein L25]]
*[[Ribosomal protein L25|Ribosomal protein L25]]
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*[[Ribosomal protein L35|Ribosomal protein L35]]
*[[Ribosomal protein L35|Ribosomal protein L35]]
*[[Ribosomal protein L39|Ribosomal protein L39]]
*[[Ribosomal protein L39|Ribosomal protein L39]]
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*[[Ribosomal protein L4|Ribosomal protein L4]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:019933108</ref><references group="xtra"/>
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</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Armache, J P.]]
[[Category: Armache, J P.]]

Revision as of 09:00, 29 September 2014

CRYO-EM STRUCTURE OF IDLE YEAST SSH1 COMPLEX BOUND TO THE YEAST 80S RIBOSOME

2wwa, resolution 8.90Å

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