1gh6
From Proteopedia
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| - | [[Image:1gh6.gif|left|200px]] | + | [[Image:1gh6.gif|left|200px]] |
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| - | '''RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN''' | + | {{Structure |
| + | |PDB= 1gh6 |SIZE=350|CAPTION= <scene name='initialview01'>1gh6</scene>, resolution 3.2Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GH6 is a [ | + | 1GH6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Simian_virus_40 Simian virus 40]. The following page contains interesting information on the relation of 1GH6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb47_1.html Simian Virus 40]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GH6 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen., Kim HY, Ahn BY, Cho Y, EMBO J. 2001 Jan 15;20(1-2):295-304. PMID:[http:// | + | Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen., Kim HY, Ahn BY, Cho Y, EMBO J. 2001 Jan 15;20(1-2):295-304. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11226179 11226179] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: tumor suppressor]] | [[Category: tumor suppressor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:23:02 2008'' |
Revision as of 09:23, 20 March 2008
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| , resolution 3.2Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN
Contents |
Overview
Inactivation of the retinoblastoma (Rb) tumor suppressor by Simian virus 40 (SV40) large T antigen is one of the central features of tumorigenesis induced by SV40. Both the N-terminal J domain and the LxCxE motif of large T antigen are required for inactivation of Rb. The crystal structure of the N-terminal region (residues 7-117) of SV40 large T antigen bound to the pocket domain of Rb reveals that large T antigen contains a four-helix bundle, and residues from helices alpha2 and alpha4 and from a loop containing the LxCxE motif participate in the interactions with Rb. The two central helices and a connecting loop in large T antigen have structural similarities with the J domains of the molecular chaperones DnaJ and HDJ-1, suggesting that large T antigen may use a chaperone mechanism for its biological function. However, there are significant differences between large T antigen and the molecular chaperones in other regions and these differences are likely to provide the specificity needed for large T antigen to inactivate Rb.
Disease
Known diseases associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]
About this Structure
1GH6 is a Protein complex structure of sequences from Homo sapiens and Simian virus 40. The following page contains interesting information on the relation of 1GH6 with [Simian Virus 40]. Full crystallographic information is available from OCA.
Reference
Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen., Kim HY, Ahn BY, Cho Y, EMBO J. 2001 Jan 15;20(1-2):295-304. PMID:11226179
Page seeded by OCA on Thu Mar 20 11:23:02 2008
