1ghq

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[[Image:1ghq.jpg|left|200px]]<br /><applet load="1ghq" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ghq.jpg|left|200px]]
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caption="1ghq, resolution 2.04&Aring;" />
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'''CR2-C3D COMPLEX STRUCTURE'''<br />
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{{Structure
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|PDB= 1ghq |SIZE=350|CAPTION= <scene name='initialview01'>1ghq</scene>, resolution 2.04&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> and <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CR2-C3D COMPLEX STRUCTURE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1GHQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GHQ OCA].
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1GHQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GHQ OCA].
==Reference==
==Reference==
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Structure of complement receptor 2 in complex with its C3d ligand., Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS, Science. 2001 Jun 1;292(5522):1725-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11387479 11387479]
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Structure of complement receptor 2 in complex with its C3d ligand., Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS, Science. 2001 Jun 1;292(5522):1725-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11387479 11387479]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: cr2]]
[[Category: cr2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:50:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:23:12 2008''

Revision as of 09:23, 20 March 2008

Image:1ghq.jpg


PDB ID 1ghq

Drag the structure with the mouse to rotate
, resolution 2.04Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CR2-C3D COMPLEX STRUCTURE


Contents

Overview

Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

Disease

Known diseases associated with this structure: C3 deficiency OMIM:[120700], Macular degeneration, age-related, 9 OMIM:[120700], Systemic lupus erythematosus, susceptibility to, 9 OMIM:[120650]

About this Structure

1GHQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of complement receptor 2 in complex with its C3d ligand., Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS, Science. 2001 Jun 1;292(5522):1725-8. PMID:11387479

Page seeded by OCA on Thu Mar 20 11:23:12 2008

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OCA

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