2wyy

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[[Image:2wyy.png|left|200px]]
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==CRYOEM MODEL OF THE VESICULAR STOMATITIS VIRUS==
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<StructureSection load='2wyy' size='340' side='right' caption='[[2wyy]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wyy]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WYY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fzm|1fzm]], [[1fzj|1fzj]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wyy RCSB], [http://www.ebi.ac.uk/pdbsum/2wyy PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wy/2wyy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Vesicular stomatitis virus (VSV) is a bullet-shaped rhabdovirus and a model system of negative-strand RNA viruses. Through direct visualization by means of cryo-electron microscopy, we show that each virion contains two nested, left-handed helices: an outer helix of matrix protein M and an inner helix of nucleoprotein N and RNA. M has a hub domain with four contact sites that link to neighboring M and N subunits, providing rigidity by clamping adjacent turns of the nucleocapsid. Side-by-side interactions between neighboring N subunits are critical for the nucleocapsid to form a bullet shape, and structure-based mutagenesis results support this description. Together, our data suggest a mechanism of VSV assembly in which the nucleocapsid spirals from the tip to become the helical trunk, both subsequently framed and rigidified by the M layer.
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{{STRUCTURE_2wyy| PDB=2wyy | SCENE= }}
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Cryo-EM model of the bullet-shaped vesicular stomatitis virus.,Ge P, Tsao J, Schein S, Green TJ, Luo M, Zhou ZH Science. 2010 Feb 5;327(5966):689-93. PMID:20133572<ref>PMID:20133572</ref>
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===CRYOEM MODEL OF THE VESICULAR STOMATITIS VIRUS===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20133572}}
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==About this Structure==
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[[2wyy]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYY OCA].
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==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein|Nucleoprotein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020133572</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Vesicular stomatitis indiana virus]]
[[Category: Vesicular stomatitis indiana virus]]
[[Category: Ge, P.]]
[[Category: Ge, P.]]

Revision as of 09:54, 29 September 2014

CRYOEM MODEL OF THE VESICULAR STOMATITIS VIRUS

2wyy, resolution 10.00Å

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