1gnh
From Proteopedia
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| - | [[Image:1gnh.gif|left|200px]] | + | [[Image:1gnh.gif|left|200px]] |
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| - | '''HUMAN C-REACTIVE PROTEIN''' | + | {{Structure |
| + | |PDB= 1gnh |SIZE=350|CAPTION= <scene name='initialview01'>1gnh</scene>, resolution 3.0Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''HUMAN C-REACTIVE PROTEIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GNH is a [ | + | 1GNH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNH OCA]. |
==Reference== | ==Reference== | ||
| - | Three dimensional structure of human C-reactive protein., Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ, Nat Struct Biol. 1996 Apr;3(4):346-54. PMID:[http:// | + | Three dimensional structure of human C-reactive protein., Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ, Nat Struct Biol. 1996 Apr;3(4):346-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8599761 8599761] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: pentraxin]] | [[Category: pentraxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:25:26 2008'' |
Revision as of 09:25, 20 March 2008
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| , resolution 3.0Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN C-REACTIVE PROTEIN
Contents |
Overview
The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned to interact with the choline group. A cleft on the pentameric face opposite to that containing the calcium site may have an important functional role. The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role.
Disease
Known disease associated with this structure: Specific granule deficiency OMIM:[600749]
About this Structure
1GNH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three dimensional structure of human C-reactive protein., Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ, Nat Struct Biol. 1996 Apr;3(4):346-54. PMID:8599761
Page seeded by OCA on Thu Mar 20 11:25:26 2008
