1go5
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1go5.jpg|left|200px]] | + | [[Image:1go5.jpg|left|200px]] |
| - | + | ||
| - | '''STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP''' | + | {{Structure |
| + | |PDB= 1go5 |SIZE=350|CAPTION= <scene name='initialview01'>1go5</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 10: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GO5 is a [ | + | 1GO5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO5 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1., Grant RP, Hurt E, Neuhaus D, Stewart M, Nat Struct Biol. 2002 Apr;9(4):247-51. PMID:[http:// | + | Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1., Grant RP, Hurt E, Neuhaus D, Stewart M, Nat Struct Biol. 2002 Apr;9(4):247-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11875519 11875519] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 22: | Line 31: | ||
[[Category: mrna export]] | [[Category: mrna export]] | ||
[[Category: nuclear transport]] | [[Category: nuclear transport]] | ||
| - | [[Category: | + | [[Category: nucleoporin]] |
[[Category: uba]] | [[Category: uba]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:25:47 2008'' |
Revision as of 09:25, 20 March 2008
| |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP
Contents |
Overview
The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. We report the solution structure of this C-terminal domain, which is based on a distinctive arrangement of four alpha-helices and is joined to the next module by a flexible 12-residue Pro-rich linker. F617A Tap suppresses FG-nucleoporin binding by the most C-terminal domain that, together with the structure of the other modules from which Tap is constructed, provides a structural context for its nuclear shuttling function.
Disease
Known diseases associated with this structure: Bare lymphocyte syndrome, type I OMIM:[170260]
About this Structure
1GO5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1., Grant RP, Hurt E, Neuhaus D, Stewart M, Nat Struct Biol. 2002 Apr;9(4):247-51. PMID:11875519
Page seeded by OCA on Thu Mar 20 11:25:47 2008
