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1god

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[[Image:1god.gif|left|200px]]<br /><applet load="1god" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1god.gif|left|200px]]
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caption="1god, resolution 2.8&Aring;" />
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'''MONOMERIC LYS-49 PHOSPHOLIPASE A2 HOMOLOGUE ISOLATED FROM THE VENOM OF CERROPHIDION (BOTHROPS) GODMANI'''<br />
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{{Structure
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|PDB= 1god |SIZE=350|CAPTION= <scene name='initialview01'>1god</scene>, resolution 2.8&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]
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|GENE=
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}}
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'''MONOMERIC LYS-49 PHOSPHOLIPASE A2 HOMOLOGUE ISOLATED FROM THE VENOM OF CERROPHIDION (BOTHROPS) GODMANI'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1GOD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cerrophidion_godmani Cerrophidion godmani]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GOD OCA].
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1GOD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cerrophidion_godmani Cerrophidion godmani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GOD OCA].
==Reference==
==Reference==
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Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani., Arni RK, Fontes MR, Barberato C, Gutierrez JM, Diaz C, Ward RJ, Arch Biochem Biophys. 1999 Jun 15;366(2):177-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10356281 10356281]
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Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani., Arni RK, Fontes MR, Barberato C, Gutierrez JM, Diaz C, Ward RJ, Arch Biochem Biophys. 1999 Jun 15;366(2):177-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10356281 10356281]
[[Category: Cerrophidion godmani]]
[[Category: Cerrophidion godmani]]
[[Category: Phospholipase A(2)]]
[[Category: Phospholipase A(2)]]
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[[Category: Gutierrez, J M.]]
[[Category: Gutierrez, J M.]]
[[Category: Ward, R J.]]
[[Category: Ward, R J.]]
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[[Category: bothrops]]
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[[Category: bothrop]]
[[Category: lys49-phospholipase a2]]
[[Category: lys49-phospholipase a2]]
[[Category: snake venom]]
[[Category: snake venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:52:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:25:48 2008''

Revision as of 09:25, 20 March 2008

Image:1god.gif


PDB ID 1god

Drag the structure with the mouse to rotate
, resolution 2.8Å
Activity: Phospholipase A(2), with EC number 3.1.1.4
Coordinates: save as pdb, mmCIF, xml



MONOMERIC LYS-49 PHOSPHOLIPASE A2 HOMOLOGUE ISOLATED FROM THE VENOM OF CERROPHIDION (BOTHROPS) GODMANI


Overview

Lys49-Phospholipase A2 (Lys49-PLA2) homologues damage membranes by a Ca2+-independent mechanism which does not involve catalytic activity. With the aim of determining the structural basis for this novel activity, we have solved the crystal structure of myotoxin-II, a Lys49-PLA2 isolated from the venom of Cerrophidion (Bothrops) godmani (godMT-II) at 2.8 A resolution by molecular replacement. The final model has been refined to a final crystallografic residual (Rfactor) of 18.8% (Rfree = 28.2%), with excellent stereochemistry. godMT-II is also monomeric in the crystalline state, and small-angle X-ray scattering results demonstrate that the protein is monomeric in solution under fisicochemical conditions similar to those used in the crystallographic studies.

About this Structure

1GOD is a Single protein structure of sequence from Cerrophidion godmani. Full crystallographic information is available from OCA.

Reference

Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani., Arni RK, Fontes MR, Barberato C, Gutierrez JM, Diaz C, Ward RJ, Arch Biochem Biophys. 1999 Jun 15;366(2):177-82. PMID:10356281

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