1gs0
From Proteopedia
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| - | [[Image:1gs0.gif|left|200px]] | + | [[Image:1gs0.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF MURINE POLY (ADP-RIBOSE) POLYMERASE-2''' | + | {{Structure |
| + | |PDB= 1gs0 |SIZE=350|CAPTION= <scene name='initialview01'>1gs0</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF MURINE POLY (ADP-RIBOSE) POLYMERASE-2''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GS0 is a [ | + | 1GS0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GS0 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2., Oliver AW, Ame JC, Roe SM, Good V, de Murcia G, Pearl LH, Nucleic Acids Res. 2004 Jan 22;32(2):456-64. Print 2004. PMID:[http:// | + | Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2., Oliver AW, Ame JC, Roe SM, Good V, de Murcia G, Pearl LH, Nucleic Acids Res. 2004 Jan 22;32(2):456-64. Print 2004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14739238 14739238] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: NAD(+) ADP-ribosyltransferase]] | [[Category: NAD(+) ADP-ribosyltransferase]] | ||
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[[Category: polymerase transferase]] | [[Category: polymerase transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:27:07 2008'' |
Revision as of 09:27, 20 March 2008
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| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Activity: | NAD(+) ADP-ribosyltransferase, with EC number 2.4.2.30 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF MURINE POLY (ADP-RIBOSE) POLYMERASE-2
Overview
Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a 'DNA-strand break sensor', which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which prevent PARP-1 from synthesizing poly(ADP-ribose) in response to DNA-breaks and potentiate the cytotoxicity of DNA damaging agents. However, with the recent discoveries of PARP-2, which has a similar DNA-damage dependent catalytic activity, and additional members containing the 'PARP catalytic' signature, the isoform selectivity and resultant pharmacological effects of existing inhibitors are brought into question. We present here the crystal structure of the catalytic fragment of murine PARP-2, at 2.8 A resolution, and compare this to the catalytic fragment of PARP-1, with an emphasis on providing a possible framework for rational drug design in order to develop future isoform-specific inhibitors.
About this Structure
1GS0 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2., Oliver AW, Ame JC, Roe SM, Good V, de Murcia G, Pearl LH, Nucleic Acids Res. 2004 Jan 22;32(2):456-64. Print 2004. PMID:14739238
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