1gv4

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[[Image:1gv4.jpg|left|200px]]<br /><applet load="1gv4" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1gv4.jpg|left|200px]]
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caption="1gv4, resolution 2.00&Aring;" />
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'''MURINE APOPTOSIS-INDUCING FACTOR (AIF)'''<br />
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{{Structure
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|PDB= 1gv4 |SIZE=350|CAPTION= <scene name='initialview01'>1gv4</scene>, resolution 2.00&Aring;
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|SITE= <scene name='pdbsite=AC1:Fad+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE DINUCLEOTIDE'>FAD</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''MURINE APOPTOSIS-INDUCING FACTOR (AIF)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1GV4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=FAD:'>FAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Fad+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA].
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1GV4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA].
==Reference==
==Reference==
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The crystal structure of the mouse apoptosis-inducing factor AIF., Mate MJ, Ortiz-Lombardia M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM, Nat Struct Biol. 2002 Jun;9(6):442-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11967568 11967568]
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The crystal structure of the mouse apoptosis-inducing factor AIF., Mate MJ, Ortiz-Lombardia M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM, Nat Struct Biol. 2002 Jun;9(6):442-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11967568 11967568]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: oxidoreductase]]
[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:54:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:28:20 2008''

Revision as of 09:28, 20 March 2008

Image:1gv4.jpg


PDB ID 1gv4

Drag the structure with the mouse to rotate
, resolution 2.00Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



MURINE APOPTOSIS-INDUCING FACTOR (AIF)


Overview

Mitochondria play a key role in apoptosis due to their capacity to release potentially lethal proteins. One of these latent death factors is cytochrome c, which can stimulate the proteolytic activation of caspase zymogens. Another important protein is apoptosis-inducing factor (AIF), a flavoprotein that can stimulate a caspase-independent cell-death pathway required for early embryonic morphogenesis. Here, we report the crystal structure of mouse AIF at 2.0 A. Its active site structure and redox properties suggest that AIF functions as an electron transferase with a mechanism similar to that of the bacterial ferredoxin reductases, its closest evolutionary homologs. However, AIF structurally differs from these proteins in some essential features, including a long insertion in a C-terminal beta-hairpin loop, which may be related to its apoptogenic functions.

About this Structure

1GV4 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the mouse apoptosis-inducing factor AIF., Mate MJ, Ortiz-Lombardia M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM, Nat Struct Biol. 2002 Jun;9(6):442-6. PMID:11967568

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