1c8z

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{{STRUCTURE_1c8z| PDB=1c8z | SCENE= }}
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==C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN==
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===C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN===
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<StructureSection load='1c8z' size='340' side='right' caption='[[1c8z]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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{{ABSTRACT_PUBMED_10591637}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1c8z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C8Z FirstGlance]. <br>
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==Disease==
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c8z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c8z RCSB], [http://www.ebi.ac.uk/pdbsum/1c8z PDBsum]</span></td></tr>
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<table>
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== Disease ==
[[http://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE]] Note=Defects in Tub are the cause of maturity-onset obesity, insulin resistance and sensory deficits.
[[http://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE]] Note=Defects in Tub are the cause of maturity-onset obesity, insulin resistance and sensory deficits.
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== Function ==
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[[http://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE]] Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).<ref>PMID:10591637</ref> <ref>PMID:11375483</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/1c8z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors.
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==Function==
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Implication of tubby proteins as transcription factors by structure-based functional analysis.,Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L Science. 1999 Dec 10;286(5447):2119-25. PMID:10591637<ref>PMID:10591637</ref>
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[[http://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE]] Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).<ref>PMID:10591637</ref><ref>PMID:11375483</ref>
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==About this Structure==
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[[1c8z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8Z OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:010591637</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Boggon, T J.]]
[[Category: Boggon, T J.]]

Revision as of 14:45, 29 September 2014

C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN

1c8z, resolution 1.90Å

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