1gxq

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[[Image:1gxq.gif|left|200px]]<br /><applet load="1gxq" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1gxq.gif|left|200px]]
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caption="1gxq, resolution 2.00&Aring;" />
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'''CRYSTAL STRUCTURE OF THE PHOB EFFECTOR DOMAIN'''<br />
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{{Structure
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|PDB= 1gxq |SIZE=350|CAPTION= <scene name='initialview01'>1gxq</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE PHOB EFFECTOR DOMAIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1GXQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXQ OCA].
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1GXQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXQ OCA].
==Reference==
==Reference==
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Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator., Blanco AG, Sola M, Gomis-Ruth FX, Coll M, Structure. 2002 May;10(5):701-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12015152 12015152]
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Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator., Blanco AG, Sola M, Gomis-Ruth FX, Coll M, Structure. 2002 May;10(5):701-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12015152 12015152]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: two-component signal transduction]]
[[Category: two-component signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:55:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:29:24 2008''

Revision as of 09:29, 20 March 2008

Image:1gxq.gif


PDB ID 1gxq

Drag the structure with the mouse to rotate
, resolution 2.00Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE PHOB EFFECTOR DOMAIN


Overview

PhoB is a signal transduction response regulator that activates nearly 40 genes in phosphate depletion conditions in E. coli and closely related bacteria. The structure of the PhoB effector domain in complex with its target DNA sequence, or pho box, reveals a novel tandem arrangement in which several monomers bind head to tail to successive 11-base pair direct-repeat sequences, coating one face of a smoothly bent double helix. The protein has a winged helix fold in which the DNA recognition elements comprise helix alpha 3, penetrating the major groove, and a beta hairpin wing interacting with a compressed minor groove via Arg219, tightly sandwiched between the DNA sugar backbones. The transactivation loops protrude laterally in an appropriate orientation to interact with the RNA polymerase sigma(70) subunit, which triggers transcription initiation.

About this Structure

1GXQ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator., Blanco AG, Sola M, Gomis-Ruth FX, Coll M, Structure. 2002 May;10(5):701-13. PMID:12015152

Page seeded by OCA on Thu Mar 20 11:29:24 2008

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