1gyw

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[[Image:1gyw.jpg|left|200px]]<br /><applet load="1gyw" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1gyw.jpg|left|200px]]
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caption="1gyw, resolution 2.40&Aring;" />
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'''GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1 A753D MUTANT'''<br />
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{{Structure
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|PDB= 1gyw |SIZE=350|CAPTION= <scene name='initialview01'>1gyw</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1 A753D MUTANT'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1GYW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYW OCA].
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1GYW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYW OCA].
==Reference==
==Reference==
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Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin., Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ, Structure. 2002 Aug;10(8):1139-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12176391 12176391]
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Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin., Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ, Structure. 2002 Aug;10(8):1139-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12176391 12176391]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: CL]]
[[Category: CL]]
[[Category: adaptor]]
[[Category: adaptor]]
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[[Category: coated pits]]
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[[Category: coated pit]]
[[Category: endocytosis]]
[[Category: endocytosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:55:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:29:53 2008''

Revision as of 09:29, 20 March 2008

Image:1gyw.jpg


PDB ID 1gyw

Drag the structure with the mouse to rotate
, resolution 2.40Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



GAMMA-ADAPTIN APPENDAGE DOMAIN FROM CLATHRIN ADAPTOR AP1 A753D MUTANT


Overview

The AP1 complex is one of a family of heterotetrameric clathrin-adaptor complexes involved in vesicular trafficking between the Golgi and endosomes. The complex has two large subunits, gamma and beta1, which can be divided into trunk, hinge, and appendage domains. The 1.8 A resolution structure of the gamma appendage is presented. The binding site for the known gamma appendage ligand gamma-synergin is mapped through creation of point mutations designed on the basis of the structure. We also show that Eps15, a protein believed to be involved in vesicle formation at the plasma membrane, is also a ligand of gamma appendage and binds to the same site as gamma-synergin. This observation explains the demonstrated brefeldinA (BFA)-sensitive colocalization of Eps15 and AP1 at the Golgi complex.

About this Structure

1GYW is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin., Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ, Structure. 2002 Aug;10(8):1139-48. PMID:12176391

Page seeded by OCA on Thu Mar 20 11:29:53 2008

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