1gz0
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1gz0.jpg|left|200px]] | + | [[Image:1gz0.jpg|left|200px]] |
| - | + | ||
| - | '''23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB''' | + | {{Structure |
| + | |PDB= 1gz0 |SIZE=350|CAPTION= <scene name='initialview01'>1gz0</scene>, resolution 2.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GZ0 is a [ | + | 1GZ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZ0 OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot., Michel G, Sauve V, Larocque R, Li Y, Matte A, Cygler M, Structure. 2002 Oct;10(10):1303-15. PMID:[http:// | + | The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot., Michel G, Sauve V, Larocque R, Li Y, Matte A, Cygler M, Structure. 2002 Oct;10(10):1303-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12377117 12377117] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 21: | Line 30: | ||
[[Category: methyltransferase]] | [[Category: methyltransferase]] | ||
[[Category: montreal-kingston bacterial structural genomics initiative]] | [[Category: montreal-kingston bacterial structural genomics initiative]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:29:57 2008'' |
Revision as of 09:30, 20 March 2008
| |||||||
| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Coordinates: | save as pdb, mmCIF, xml | ||||||
23S RIBOSOMAL RNA G2251 2'O-METHYLTRANSFERASE RLMB
Overview
In Escherichia coli, RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. The crystal structure of this 2'O-methyltransferase has been determined at 2.5 A resolution. RlmB consists of an N-terminal domain connected by a flexible extended linker to a catalytic C-terminal domain and forms a dimer in solution. The C-terminal domain displays a divergent methyltransferase fold with a unique knotted region, and lacks the classic AdoMet binding site features. The N-terminal domain is similar to ribosomal proteins L7 and L30, suggesting a role in 23S rRNA recognition. The conserved residues in this novel family of 2'O-methyltransferases cluster in the knotted region, suggesting the location of the catalytic and AdoMet binding sites.
About this Structure
1GZ0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot., Michel G, Sauve V, Larocque R, Li Y, Matte A, Cygler M, Structure. 2002 Oct;10(10):1303-15. PMID:12377117
Page seeded by OCA on Thu Mar 20 11:29:57 2008
