1h5a

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[[Image:1h5a.gif|left|200px]]<br /><applet load="1h5a" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1h5a.gif|left|200px]]
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caption="1h5a, resolution 1.60&Aring;" />
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'''STRUCTURE OF FERRIC HORSERADISH PEROXIDASE C1A IN COMPLEX WITH ACETATE'''<br />
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{{Structure
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|PDB= 1h5a |SIZE=350|CAPTION= <scene name='initialview01'>1h5a</scene>, resolution 1.60&Aring;
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|SITE= <scene name='pdbsite=CAA:Hem+Binding+Site+For+Chain+A'>CAA</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7]
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|GENE=
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}}
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'''STRUCTURE OF FERRIC HORSERADISH PEROXIDASE C1A IN COMPLEX WITH ACETATE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1H5A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Known structural/functional Site: <scene name='pdbsite=CAA:Hem+Binding+Site+For+Chain+A'>CAA</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5A OCA].
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1H5A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5A OCA].
==Reference==
==Reference==
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The catalytic pathway of horseradish peroxidase at high resolution., Berglund GI, Carlsson GH, Smith AT, Szoke H, Henriksen A, Hajdu J, Nature. 2002 May 23;417(6887):463-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12024218 12024218]
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The catalytic pathway of horseradish peroxidase at high resolution., Berglund GI, Carlsson GH, Smith AT, Szoke H, Henriksen A, Hajdu J, Nature. 2002 May 23;417(6887):463-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12024218 12024218]
[[Category: Armoracia rusticana]]
[[Category: Armoracia rusticana]]
[[Category: Peroxidase]]
[[Category: Peroxidase]]
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[[Category: peroxidase]]
[[Category: peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:57:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:32:23 2008''

Revision as of 09:32, 20 March 2008

Image:1h5a.gif


PDB ID 1h5a

Drag the structure with the mouse to rotate
, resolution 1.60Å
Sites:
Ligands: , and
Activity: Peroxidase, with EC number 1.11.1.7
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF FERRIC HORSERADISH PEROXIDASE C1A IN COMPLEX WITH ACETATE


Overview

A molecular description of oxygen and peroxide activation in biological systems is difficult, because electrons liberated during X-ray data collection reduce the active centres of redox enzymes catalysing these reactions. Here we describe an effective strategy to obtain crystal structures for high-valency redox intermediates and present a three-dimensional movie of the X-ray-driven catalytic reduction of a bound dioxygen species in horseradish peroxidase (HRP). We also describe separate experiments in which high-resolution structures could be obtained for all five oxidation states of HRP, showing such structures with preserved redox states for the first time.

About this Structure

1H5A is a Single protein structure of sequence from Armoracia rusticana. Full crystallographic information is available from OCA.

Reference

The catalytic pathway of horseradish peroxidase at high resolution., Berglund GI, Carlsson GH, Smith AT, Szoke H, Henriksen A, Hajdu J, Nature. 2002 May 23;417(6887):463-8. PMID:12024218

Page seeded by OCA on Thu Mar 20 11:32:23 2008

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