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1h6i

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[[Image:1h6i.gif|left|200px]]<br /><applet load="1h6i" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1h6i.gif|left|200px]]
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caption="1h6i, resolution 3.54&Aring;" />
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'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1'''<br />
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{{Structure
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|PDB= 1h6i |SIZE=350|CAPTION= <scene name='initialview01'>1h6i</scene>, resolution 3.54&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1H6I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6I OCA].
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1H6I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6I OCA].
==Reference==
==Reference==
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A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11532455 11532455]
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A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11532455 11532455]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: water channel]]
[[Category: water channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:57:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:32:54 2008''

Revision as of 09:32, 20 March 2008

Image:1h6i.gif


PDB ID 1h6i

Drag the structure with the mouse to rotate
, resolution 3.54Å
Coordinates: save as pdb, mmCIF, xml



A REFINED STRUCTURE OF HUMAN AQUAPORIN 1


Contents

Overview

A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.

Disease

Known diseases associated with this structure: Aquaporin-1 deficiency OMIM:[107776], Blood group, Colton OMIM:[107776]

About this Structure

1H6I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455

Page seeded by OCA on Thu Mar 20 11:32:54 2008

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