1z6o

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[[Image:1z6o.png|left|200px]]
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==Crystal Structure of Trichoplusia ni secreted ferritin==
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<StructureSection load='1z6o' size='340' side='right' caption='[[1z6o]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z6o]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichoplusia_ni Trichoplusia ni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z6O FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z6o RCSB], [http://www.ebi.ac.uk/pdbsum/1z6o PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z6o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ferritins are iron storage proteins made of 24 subunits forming a hollow spherical shell. Vertebrate ferritins contain varying ratios of heavy (H) and light (L) chains; however, known ferritin structures include only one type of chain and have octahedral symmetry. Here, we report the 1.9A structure of a secreted insect ferritin from Trichoplusia ni, which reveals equal numbers of H and L chains arranged with tetrahedral symmetry. The H/L-chain interface includes complementary features responsible for ordered assembly of the subunits. The H chain contains a ferroxidase active site resembling that of vertebrate H chains with an endogenous, bound iron atom. The L chain lacks the residues that form a putative iron core nucleation site in vertebrate L chains. Instead, a possible nucleation site is observed at the L chain 3-fold pore. The structure also reveals inter- and intrasubunit disulfide bonds, mostly in the extended N-terminal regions unique to insect ferritins. The symmetrical arrangement of H and L chains and the disulfide crosslinks reflect adaptations of insect ferritin to its role as a secreted protein.
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{{STRUCTURE_1z6o| PDB=1z6o | SCENE= }}
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Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains.,Hamburger AE, West AP Jr, Hamburger ZA, Hamburger P, Bjorkman PJ J Mol Biol. 2005 Jun 10;349(3):558-69. Epub 2005 Apr 12. PMID:15896348<ref>PMID:15896348</ref>
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===Crystal Structure of Trichoplusia ni secreted ferritin===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15896348}}
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==See Also==
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*[[Ferritin|Ferritin]]
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==About this Structure==
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== References ==
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[[1z6o]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichoplusia_ni Trichoplusia ni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6O OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015896348</ref><references group="xtra"/>
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[[Category: Trichoplusia ni]]
[[Category: Trichoplusia ni]]
[[Category: Bjorkman, P J.]]
[[Category: Bjorkman, P J.]]

Revision as of 18:53, 29 September 2014

Crystal Structure of Trichoplusia ni secreted ferritin

1z6o, resolution 1.91Å

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