1xpn

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[[Image:1xpn.png|left|200px]]
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==NMR structure of P. aeruginosa protein PA1324: Northeast Structural Genomics Consortium target PaP1==
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<StructureSection load='1xpn' size='340' side='right' caption='[[1xpn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XPN FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA1324 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 Pseudomonas aeruginosa PAO1])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xpn RCSB], [http://www.ebi.ac.uk/pdbsum/1xpn PDBsum], [http://www.topsan.org/Proteins/NESGC/1xpn TOPSAN]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xpn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pseudomonas aeruginosa is the prototypical biofilm-forming gram-negative opportunistic human pathogen. P. aeruginosa is causatively associated with nosocomial infections and with cystic fibrosis. Antibiotic resistance in some strains adds to the inherent difficulties that result from biofilm formation when treating P. aeruginosa infections. Transcriptional profiling studies suggest widespread changes in the proteome during quorum sensing and biofilm development. Many of the proteins found to be upregulated during these processes are poorly characterized from a functional standpoint. Here, we report the solution NMR structure of PA1324, a protein of unknown function identified in these studies, and provide a putative biological functional assignment based on the observed prealbumin-like fold and FAST-NMR ligand screening studies. PA1324 is postulated to be involved in the binding and transport of sugars or polysaccharides associated with the peptidoglycan matrix during biofilm formation.
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{{STRUCTURE_1xpn| PDB=1xpn | SCENE= }}
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Structure and function of Pseudomonas aeruginosa protein PA1324 (21-170).,Mercier KA, Cort JR, Kennedy MA, Lockert EE, Ni S, Shortridge MD, Powers R Protein Sci. 2009 Mar;18(3):606-18. PMID:19241370<ref>PMID:19241370</ref>
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===NMR structure of P. aeruginosa protein PA1324: Northeast Structural Genomics Consortium target PaP1===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19241370}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1xpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPN OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019241370</ref><references group="xtra"/>
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[[Category: Pseudomonas aeruginosa pao1]]
[[Category: Pseudomonas aeruginosa pao1]]
[[Category: Cort, J R.]]
[[Category: Cort, J R.]]

Revision as of 19:06, 29 September 2014

NMR structure of P. aeruginosa protein PA1324: Northeast Structural Genomics Consortium target PaP1

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