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2j8x

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[[Category: uracil-dna glycosylase inhibitor]]
[[Category: uracil-dna glycosylase inhibitor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:28:23 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:27:17 2007''

Revision as of 15:22, 30 October 2007

Image:2j8x.gif

2j8x, resolution 2.30Å

Drag the structure with the mouse to rotate

EPSTEIN-BARR VIRUS URACIL-DNA GLYCOSYLASE IN COMPLEX WITH UGI FROM PBS-2

Overview

Epstein-Barr virus (EBV) is a human gamma-herpesvirus. Within its 86 open, reading frame containing genome, two enzymes avoiding uracil incorporation, into DNA can be found: uracil triphosphate hydrolase and uracil-DNA, glycosylase (UNG). The latter one excises uracil bases that are due to, cytosine deamination or uracil misincorporation from double-stranded DNA, substrates. The EBV enzyme belongs to family 1 UNGs. We solved the, three-dimensional structure of EBV UNG in complex with the uracil-DNA, glycosylase inhibitor protein (Ugi) from bacteriophage PBS-2 at a, resolution of 2.3 A by X-ray crystallography. The structure of EBV UNG, encoded by the BKRF3 reading frame shows the excellent global structural, conservation within the solved examples of family 1 enzymes. Four out of, the ... [(full description)]

About this Structure

2J8X is a [Protein complex] structure of sequences from [Human herpesvirus 4] and [Phage pbs1] with URE as [ligand]. Active as [Uridine nucleosidase], with EC number [3.2.2.3]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

New insights on the role of the gamma-herpesvirus uracil-DNA glycosylase leucine loop revealed by the structure of the Epstein-Barr virus enzyme in complex with an inhibitor protein., Geoui T, Buisson M, Tarbouriech N, Burmeister WP, J Mol Biol. 2007 Feb 9;366(1):117-31. Epub 2006 Nov 7. PMID:17157317

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