1ha1

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[[Image:1ha1.gif|left|200px]]<br /><applet load="1ha1" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ha1.gif|left|200px]]
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caption="1ha1, resolution 1.75&Aring;" />
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'''HNRNP A1 (RBD1,2) FROM HOMO SAPIENS'''<br />
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{{Structure
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|PDB= 1ha1 |SIZE=350|CAPTION= <scene name='initialview01'>1ha1</scene>, resolution 1.75&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''HNRNP A1 (RBD1,2) FROM HOMO SAPIENS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HA1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA1 OCA].
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1HA1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA1 OCA].
==Reference==
==Reference==
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Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution., Shamoo Y, Krueger U, Rice LM, Williams KR, Steitz TA, Nat Struct Biol. 1997 Mar;4(3):215-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9164463 9164463]
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Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution., Shamoo Y, Krueger U, Rice LM, Williams KR, Steitz TA, Nat Struct Biol. 1997 Mar;4(3):215-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9164463 9164463]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: rrm]]
[[Category: rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:59:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:34:20 2008''

Revision as of 09:34, 20 March 2008

Image:1ha1.gif


PDB ID 1ha1

Drag the structure with the mouse to rotate
, resolution 1.75Å
Coordinates: save as pdb, mmCIF, xml



HNRNP A1 (RBD1,2) FROM HOMO SAPIENS


Overview

Heterogeneous ribonucleoprotein A1 (hnRNP A1) is an abundant eukaryotic nuclear RNA binding protein. A1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm and may modulate splice site selection. The crystal structure of A1(RBD1,2) reveals two independently-folded RNA binding domains (RBDs) connected by a flexible linker. Both RBDs are structurally homologous to the U1A(RBD1), and have their RNA binding platforms oriented in an anti-parallel fashion. The anti-parallel arrangement of the A1 RNA binding platforms suggests mechanisms for RNA condensation and ways of bringing together distant RNA sequences for RNA metabolism such as splicing or transport.

About this Structure

1HA1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution., Shamoo Y, Krueger U, Rice LM, Williams KR, Steitz TA, Nat Struct Biol. 1997 Mar;4(3):215-22. PMID:9164463

Page seeded by OCA on Thu Mar 20 11:34:20 2008

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