1ha0
From Proteopedia
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| - | [[Image:1ha0.gif|left|200px]] | + | [[Image:1ha0.gif|left|200px]] |
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| - | '''HEMAGGLUTININ PRECURSOR HA0''' | + | {{Structure |
| + | |PDB= 1ha0 |SIZE=350|CAPTION= <scene name='initialview01'>1ha0</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''HEMAGGLUTININ PRECURSOR HA0''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HA0 is a [ | + | 1HA0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA0 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation., Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC, Cell. 1998 Oct 30;95(3):409-17. PMID:[http:// | + | Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation., Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC, Cell. 1998 Oct 30;95(3):409-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9814710 9814710] |
[[Category: Influenza a virus]] | [[Category: Influenza a virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: virus/viral protein]] | [[Category: virus/viral protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:34:20 2008'' |
Revision as of 09:34, 20 March 2008
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| , resolution 2.80Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HEMAGGLUTININ PRECURSOR HA0
Overview
The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent surface loop adjacent to a novel cavity; cleavage results in structural rearrangements in which the nonpolar amino acids near the new amino terminus bury ionizable residues in the cavity that are implicated in the low-pH-induced conformational change. Amino acid insertions at the cleavage site in HAs of virulent avian viruses and those of viruses isolated from the recent severe outbreak of influenza in humans in Hong Kong would extend this surface loop, facilitating intracellular cleavage.
About this Structure
1HA0 is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.
Reference
Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation., Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC, Cell. 1998 Oct 30;95(3):409-17. PMID:9814710
Page seeded by OCA on Thu Mar 20 11:34:20 2008
