1z66

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[[Image:1z66.png|left|200px]]
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==NMR solution structure of domain III of E-protein of tick-borne Langat flavivirus (no RDC restraints)==
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<StructureSection load='1z66' size='340' side='right' caption='[[1z66]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z66]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Langat_virus Langat virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z66 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yzo|1yzo]], [[1svb|1svb]], [[1pjw|1pjw]], [[1s6n|1s6n]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z66 RCSB], [http://www.ebi.ac.uk/pdbsum/1z66 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z66_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Flaviviruses cause many human diseases, including dengue fever, yellow fever, West Nile viral encephalitis, and hemorrhagic fevers, and are transmitted to their vertebrate hosts by infected mosquitoes and ticks. Domain III of the envelope protein (E-D3) is considered to be the primary viral determinant involved in the virus-host-cell receptor interaction, and thus represents an excellent target for antiviral drug development. Langat (LGT) virus is a naturally attenuated BSL-2 TBE virus and is a model for the pathogenic BSL-3 and BSL-4 viruses in the serogroup. We have determined the solution structure of LGT-E-D3 using heteronuclear NMR spectroscopy. The backbone dynamics of LGT-E-D3 have been investigated using 15N relaxation measurements. A detailed analysis of the solution structure and dynamics of LGT-E-D3 suggests potential residues that could form a surface for molecular recognition, and thereby represent a target site for antiviral therapeutics design.
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{{STRUCTURE_1z66| PDB=1z66 | SCENE= }}
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NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition.,Mukherjee M, Dutta K, White MA, Cowburn D, Fox RO Protein Sci. 2006 Jun;15(6):1342-55. PMID:16731969<ref>PMID:16731969</ref>
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===NMR solution structure of domain III of E-protein of tick-borne Langat flavivirus (no RDC restraints)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16731969}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1z66]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Langat_virus Langat virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z66 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016731969</ref><references group="xtra"/>
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[[Category: Langat virus]]
[[Category: Langat virus]]
[[Category: Cowburn, D.]]
[[Category: Cowburn, D.]]

Revision as of 19:44, 29 September 2014

NMR solution structure of domain III of E-protein of tick-borne Langat flavivirus (no RDC restraints)

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