1wmv

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{{STRUCTURE_1wmv| PDB=1wmv | SCENE= }}
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==Solution structure of the second WW domain of WWOX==
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===Solution structure of the second WW domain of WWOX===
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<StructureSection load='1wmv' size='340' side='right' caption='[[1wmv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref><ref>PMID:15266310</ref><ref>PMID:15073125</ref><ref>PMID:15131042</ref><ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref><ref>PMID:15266310</ref><ref>PMID:15073125</ref><ref>PMID:15131042</ref><ref>PMID:16223882</ref>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum]</span></td></tr>
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==Function==
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<table>
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[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref><ref>PMID:15548692</ref><ref>PMID:15070730</ref><ref>PMID:16061658</ref><ref>PMID:16219768</ref><ref>PMID:19366691</ref><ref>PMID:19465938</ref>
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== Disease ==
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[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
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==About this Structure==
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== Function ==
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[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA].
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[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>
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== Evolutionary Conservation ==
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==Reference==
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[[Image:Consurf_key_small.gif|200px|right]]
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<references group="xtra"/><references/>
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/1wmv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Booker, G W.]]
[[Category: Booker, G W.]]

Revision as of 20:16, 29 September 2014

Solution structure of the second WW domain of WWOX

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