1x3s

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{{STRUCTURE_1x3s| PDB=1x3s | SCENE= }}
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==Crystal structure of human Rab18 in complex with Gppnhp==
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===Crystal structure of human Rab18 in complex with Gppnhp===
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<StructureSection load='1x3s' size='340' side='right' caption='[[1x3s]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1x3s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X3S FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN]] Defects in RAB18 are the cause of Warburg micro syndrome type 3 (WARBM3) [MIM:[http://omim.org/entry/614222 614222]]. WARBM3 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.<ref>PMID:21473985</ref>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==Function==
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x3s RCSB], [http://www.ebi.ac.uk/pdbsum/1x3s PDBsum], [http://www.topsan.org/Proteins/RSGI/1x3s TOPSAN]</span></td></tr>
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[[http://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN]] Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.<ref>PMID:21473985</ref>
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<table>
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== Disease ==
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==About this Structure==
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[[http://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN]] Defects in RAB18 are the cause of Warburg micro syndrome type 3 (WARBM3) [MIM:[http://omim.org/entry/614222 614222]]. WARBM3 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.<ref>PMID:21473985</ref>
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[[1x3s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X3S OCA].
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== Function ==
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[[http://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN]] Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.<ref>PMID:21473985</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/1x3s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[GTP-binding protein|GTP-binding protein]]
*[[GTP-binding protein|GTP-binding protein]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, L.]]
[[Category: Chen, L.]]

Revision as of 21:15, 29 September 2014

Crystal structure of human Rab18 in complex with Gppnhp

1x3s, resolution 1.32Å

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