1hh2

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[[Image:1hh2.jpg|left|200px]]<br /><applet load="1hh2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1hh2.jpg|left|200px]]
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caption="1hh2, resolution 2.1&Aring;" />
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'''CRYSTAL STRUCTURE OF NUSA FROM THERMOTOGA MARITIMA'''<br />
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{{Structure
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|PDB= 1hh2 |SIZE=350|CAPTION= <scene name='initialview01'>1hh2</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= NUSA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
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}}
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'''CRYSTAL STRUCTURE OF NUSA FROM THERMOTOGA MARITIMA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HH2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HH2 OCA].
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1HH2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HH2 OCA].
==Reference==
==Reference==
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An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA., Worbs M, Bourenkov GP, Bartunik HD, Huber R, Wahl MC, Mol Cell. 2001 Jun;7(6):1177-89. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11430821 11430821]
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An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA., Worbs M, Bourenkov GP, Bartunik HD, Huber R, Wahl MC, Mol Cell. 2001 Jun;7(6):1177-89. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11430821 11430821]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: transcription regulation]]
[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:01:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:37:05 2008''

Revision as of 09:37, 20 March 2008

Image:1hh2.jpg


PDB ID 1hh2

Drag the structure with the mouse to rotate
, resolution 2.1Å
Gene: NUSA (Thermotoga maritima)
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF NUSA FROM THERMOTOGA MARITIMA


Overview

The crystal structure of Thermotoga maritima NusA, a transcription factor involved in pausing, termination, and antitermination processes, reveals a four-domain, rod-shaped molecule. An N-terminal alpha/beta portion, a five-stranded beta-barrel (S1 domain), and two K-homology (KH) modules create a continuous spine of positive electrostatic potential, suitable for nonspecific mRNA attraction. Homology models suggest how, in addition, specific mRNA regulatory sequences can be recognized by the S1 and KH motifs. An arrangement of multiple S1 and KH domains mediated by highly conserved residues is seen, creating an extended RNA binding surface, a paradigm for other proteins with similar domain arrays. Structural and mutational analyses indicate that the motifs cooperate, modulating strength and specificity of RNA binding.

About this Structure

1HH2 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA., Worbs M, Bourenkov GP, Bartunik HD, Huber R, Wahl MC, Mol Cell. 2001 Jun;7(6):1177-89. PMID:11430821

Page seeded by OCA on Thu Mar 20 11:37:05 2008

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