1hig

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[[Image:1hig.gif|left|200px]]<br /><applet load="1hig" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1hig.gif|left|200px]]
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caption="1hig, resolution 3.5&Aring;" />
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'''THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.'''<br />
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{{Structure
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|PDB= 1hig |SIZE=350|CAPTION= <scene name='initialview01'>1hig</scene>, resolution 3.5&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HIG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HIG OCA].
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1HIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HIG OCA].
==Reference==
==Reference==
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Three-dimensional structure of recombinant human interferon-gamma., Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, Bugg CE, Science. 1991 May 3;252(5006):698-702. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1902591 1902591]
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Three-dimensional structure of recombinant human interferon-gamma., Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, Bugg CE, Science. 1991 May 3;252(5006):698-702. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1902591 1902591]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: glycoprotein]]
[[Category: glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:01:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:37:28 2008''

Revision as of 09:37, 20 March 2008

Image:1hig.gif


PDB ID 1hig

Drag the structure with the mouse to rotate
, resolution 3.5Å
Coordinates: save as pdb, mmCIF, xml



THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.


Contents

Overview

The x-ray crystal structure of recombinant human interferon-gamma has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-gamma, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily alpha helical, with six helices in each subunit that comprise approximately 62 percent of the structure; there is no beta sheet. The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions.

Disease

Known diseases associated with this structure: AIDS, rapid progression to OMIM:[147570], Aplastic anemia OMIM:[147570], Hepatitis C virus, resistance to OMIM:[147570], Interferon, immune, deficiency OMIM:[147570], TSC2 angiomyolipomas, renal, modifier of OMIM:[147570], Tuberculosis, susceptibility to OMIM:[147570]

About this Structure

1HIG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of recombinant human interferon-gamma., Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, Bugg CE, Science. 1991 May 3;252(5006):698-702. PMID:1902591

Page seeded by OCA on Thu Mar 20 11:37:28 2008

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