1ugv

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{{STRUCTURE_1ugv| PDB=1ugv | SCENE= }}
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==Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)==
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===Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)===
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<StructureSection load='1ugv' size='340' side='right' caption='[[1ugv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UGV FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA hg04539 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [http://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [http://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr>
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<table>
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== Disease ==
[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[http://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[http://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
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== Function ==
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==Function==
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[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] GTPase-activating protein for RHOA and CDC42.
[[http://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN]] GTPase-activating protein for RHOA and CDC42.
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[1ugv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aoki, M.]]
[[Category: Aoki, M.]]

Revision as of 21:44, 29 September 2014

Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)

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