1x4q

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{{STRUCTURE_1x4q| PDB=1x4q | SCENE= }}
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==Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)==
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===Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)===
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<StructureSection load='1x4q' size='340' side='right' caption='[[1x4q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1X4Q FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[http://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref><ref>PMID:12714658</ref><ref>PMID:17932117</ref>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRPF3, HPRP3, PRP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1x4q RCSB], [http://www.ebi.ac.uk/pdbsum/1x4q PDBsum], [http://www.topsan.org/Proteins/RSGI/1x4q TOPSAN]</span></td></tr>
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==Function==
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18) [MIM:[http://omim.org/entry/601414 601414]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP18 inheritance is autosomal dominant.<ref>PMID:11773002</ref> <ref>PMID:12714658</ref> <ref>PMID:17932117</ref>
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== Function ==
[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.
[[http://www.uniprot.org/uniprot/PRPF3_HUMAN PRPF3_HUMAN]] Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[1x4q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4Q OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein|Nucleoprotein]]
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: He, F.]]
[[Category: He, F.]]

Revision as of 22:04, 29 September 2014

Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)

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