1hla

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[[Image:1hla.gif|left|200px]]<br /><applet load="1hla" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1hla.gif|left|200px]]
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caption="1hla, resolution 3.5&Aring;" />
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'''STRUCTURE OF THE HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN, HLA-A2'''<br />
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{{Structure
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|PDB= 1hla |SIZE=350|CAPTION= <scene name='initialview01'>1hla</scene>, resolution 3.5&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF THE HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN, HLA-A2'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HLA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLA OCA].
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1HLA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLA OCA].
==Reference==
==Reference==
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Structure of the human class I histocompatibility antigen, HLA-A2., Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC, Nature. 1987 Oct 8-14;329(6139):506-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=3309677 3309677]
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Structure of the human class I histocompatibility antigen, HLA-A2., Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC, Nature. 1987 Oct 8-14;329(6139):506-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3309677 3309677]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: histocompatibility antigen]]
[[Category: histocompatibility antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:02:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:38:34 2008''

Revision as of 09:38, 20 March 2008

Image:1hla.gif


PDB ID 1hla

Drag the structure with the mouse to rotate
, resolution 3.5Å
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN, HLA-A2


Contents

Overview

The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices. A large groove between the alpha-helices provides a binding site for processed foreign antigens. An unknown 'antigen' is found in this site in crystals of purified HLA-A2.

Disease

Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]

About this Structure

1HLA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the human class I histocompatibility antigen, HLA-A2., Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC, Nature. 1987 Oct 8-14;329(6139):506-12. PMID:3309677

Page seeded by OCA on Thu Mar 20 11:38:34 2008

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